Upregulated TRPC3 expression and function in vascular smooth muscle during hypertension

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Upregulated TRPC3 and Downregulated TRPC1 Channel Expression during Hypertension is Associated with Increased Vascular Contractility in Rat

Transient receptor potential (TRP) C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility. In the present study, we determined the effect of systemic hypertension on TRPC1/TRPC3 channel expression and vascular contractility in rat carotid artery (CA). CA were studied from male spontaneously hypertensive rats (SHR), Wist...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2009

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.23.1_supplement.1018.11